Abstract:The NSFC-Guangdong Joint Fund, jointly established by the National Natural Science Foundation of China and the People's Government of Guangdong Province, aims to play the guiding role of the National Natural Science Foundation of China, meet major national needs, focus on meeting the needs of economic and social development in Guangdong Province and surrounding regions, attract and Bring together outstanding scientists across the country to solve major scientific and key technical issues in the development of science and technology strategies. Through the comparative analysis with the joint funds of Yunnan, Xinjiang, Henan and Fujian, the problems and reasons in the process of compiling the joint fund guide were sorted out, and the countermeasures and suggestions were put forward in combination with the overall deployment of the deepening reform of the Science Fund in the new era. The high-efficiency implementation of the Guangdong Regional Innovation and Development Joint Fund in the new period of "14th Five-Year Plan" and the key research directions of the basic research work in Guangdong Province provide decision support, thereby further promoting the improvement of regional independent innovation capabilities.