Abstract:Based on summarizing the connotation and development of science and technology innovation centers of global urban agglomerations, this paper takes the San Francisco Bay Area, the London Bay Area, the Tokyo Bay Area and the Guangdong-Hong Kong-Macao Greater Bay Area as examples to analyze and summarize their construction practices and measures, and sort out their experiences. Combining the existing foundation and challenges, this article proposes suggestions for Chengdu-Chongqing Region, including to further improve cooperative innovation mechanism, strengthen collaborative innovation pattern, cultivate diversified innovation entities, inspire major original innovation, build key core industries, improve the science and technology service system, optimize the innovation cooperation network, and gather excellent science and innovation talents.