Abstract:Science and technology finance is the organic combination of science and technology innovation chain and financial capital chain. The support of science and technology finance is indispensable in different development stages of high-tech industry. Taking 11 provinces and cities in the Yangtze River economic belt as the research object, from the perspective of industrial life cycle, this paper uses logistic model to study and judge the development stage of high-tech industry in the Yangtze River economic belt, and analyzes the relationship and influence between science and technology finance and different stages of high-tech industry development. The research shows that the lower reaches of the Yangtze River economic belt first entered the late stage of rapid development; Science and technology finance significantly affects the development of regional high-tech industry through science and technology resources, government financial investment in science and technology and market financing; Technology capitalization can not meet the needs of the rapid development of high-tech industries in the Yangtze River economic belt. The policies and tools of science, technology and finance support the development stages of high-tech industries in different regions in the upper, middle and lower reaches of the Yangtze River economic belt.