Abstract:Under the background of the globalization of new technology and the new round of technological industrial revolution, under the major national strategic opportunity of the “dual superposition” of the Guangdong-Hong Kong-Macao Greater Bay Area and the Shenzhen Pilot Demonstration Zone of Socialism with Chinese Characteristics, it is important to explore a new path for technological innovation and development in Guangdong Realistic meaning. Based on the SWOT-AHP analysis model, taking Guangdong’s “14th Five-Year Plan” period scientific and technological innovation development as a sample, taking advantages, disadvantages, opportunities and challenges as the criterion layer, clarifying 16 factors as the indicator layer, quantifying and calculating the importance of each factor Weight, draw the strategic quadrilateral to judge the overall direction of the strategy. The results show that Guangdong science and technology innovation is generally located in the opportunistic strategic area of the SO development strategic zone. It should implement pioneering strategies to promote the leap of Guangdong's regional innovation capabilities.