Abstract:The research and judgment of global science and technology development trend is to judge and analyze the trend of science and technology, international competition, industrial form and social relations for a period of time in the future. It is of great significance for the formulation and planning of science and technology strategy. Taking 2035 as the outlook, this article analyzes the global technological development, innovation paradigm, basic science, R D organization, and social impact, it believes that future technological innovation will have a decisive impact on human economic and social development. New technologies, new organizations, new industries, new business formats will continue to emerge, new R D organizations will undergo advanced evolution, and technology applications will reshape the economic society and industrial structure. As one of the countries with the fastest progress in the field of scientific and technological innovation, China faces potential risks such as partial decoupling of Chinese and American science and technology, international technology export control, restricted application of emerging technologies, and increased uncertainty in scientific research ethics. In this regard, it is proposed to strengthen forward-looking forecasts of strategic frontier technologies, strengthen national scientific and technological cooperation, build national strategic scientific and technological strength, build a new national system for core technology research, and accelerate the transformation of government management functions.