Abstract:Under the new situation, Xi Jinping's series of important exposition on scientific and technological innovation in the new era has established a comprehensive strategic orientation for deeply promoting the development and reform of scientific and technological innovation in colleges and universities with industrial characteristics. Through word cloud analysis and other methods, this article study and grasp the essence of Xi Jinping's series of important exposition on scientific and technological innovation in the new era. In order to solve the problems existing in the development of scientific and technological innovation in colleges and universities with industry characteristics, such as single dominant discipline, lack of basic discipline, limited funds for running schools and all kinds of resources, and simple evaluation system for professional technology posts and titles, the article puts forward some suggestions on the construction of scientific and technological innovation system of colleges and universities with industry characteristics by taking the exposition as the guiding direction, including the purpose of serving the development of the industry, improving the reform of institutional mechanisms and the construction of the innovation ecological environment, adopting new measures in talent training system, as well as strengthening interdisciplinary construction and foreign exchanges.