Abstract:Given the lack of research on how resource-based enterprises play the main role of technical innovation, this study takes five Fortune 500 resource-based enterprises as the research objects, adopts the multi-case study method, deeply analyzes the internal mechanisms and key elements of resource-based enterprises to improve independent innovation performance by playing the main role of technical innovation, and puts forward corresponding theoretical propositions. This study draws the following conclusions: the important factor to promote the improvement of independent innovation performance of resource-based enterprises is to play the main role of enterprise demand; the basic guarantee is to play the main role of enterprise R&D investment; the important path is to play to the main role of industry-university-research collaborative innovation; the important support is to play the main role of enterprise R&D organization; and the key element is to play the main role of enterprise talent training. The research conclusions suggest that resource-based enterprises should strengthen R&D investment, build industry-university-research alliance portfolios with themselves as the main body, build internal technology R&D platforms, cultivate talents, and improve talent incentive policies and so on, so as to enhance the main role of technical innovation and improve independent innovation performance.