Abstract:The implementation of the "new infrastructure" strategic layout is the hardware guarantee for the development of the digital economy under the big data informatization. In recent years, the Yellow River Basin has promoted data elements to participate in more value creation and distribution, thanks to the role of the digital economy in the output of technological innovation. Based on this, this article conducts an empirical study on the relationship between the output of scientific and technological innovation and the digital economy in the Yellow River Basin from 2009 to 2019. Research shows that the development of the digital economy is an important supporting force to promote the output of scientific and technological innovation, showing a significant spatial spillover effect. Therefore, promoting the development process of the digital economy under the economic and social form is conducive to improving the performance of scientific and technological innovation, and it is also the need for high-quality development and data value mining in the Yellow River Basin.