Abstract:Based on the development status of science and technology services in Guangdong, Hong Kong and Macao, and the theoretical "black box" of collaborative innovation in science and technology services, we construct the Guangdong, Hong Kong and Macao Bay Area collaborative innovation system of science and technology services driven by science and technology service organizations, and the problem of “Who collaborates, collaborate for whom, how to collaborate” is a theoretical problem that urgently needs to be solved in the construction of collaborative innovation system. By reviewing the related researches on the science and technology services system and innovation ecosystem, we define the connotation and characteristics of the collaborative innovation system of science and technology services. On this basis, based on the idea of system integration and the theory of innovation ecosystem, the Guangdong, Hong Kong and Macao Bay Area collaborative innovation system of science and technology services is constructed: university knowledge production system, institutional technology research and development system, innovative enterprise development system, and science and technology intermediary service system. Finally, based on the perspective of subject linkage, we put forward the countermeasures and suggestions for the construction and development of the Guangdong, Hong Kong and Macao Bay Area collaborative innovation system of science and technology services.