Abstract:The role of scientific research development in economic progress and national innovation development has become increasingly apparent, conducting evaluation research on regional research competitiveness can enrich theoretical research and guide related practices. This research takes the five national urban agglomerations in the optimization and promotion category in the 14th Five-Year Plan as the research object. By constructing an evaluation system for regional scientific research competitiveness and using the entropy method combined with the TOPSIS model to carry out empirical research on the entire urban agglomeration and the provinces in the region. Results show that there is a significant gap in the level of research competitiveness among the eastern, central and western urban agglomerations and presenting a pattern of the Pearl River Delta>Beijing-Tianjin-Hebei>Yangtze River Delta>Triangle of Central China>Chengdu-Chongqing City Group. The central cities of various urban agglomerations have become important growth poles for regional innovation. The problem of coordinated development within the region is very prominent, especially the regional differences in the Beijing-Tianjin-Hebei urban agglomeration are the first among the five urban agglomerations. Although the Triangle of Central China and Chengdu-Chongqing City Group are in the lower reaches of the five urban agglomerations, the overall strength of the research competitiveness of the provinces in the region is relatively balanced.