Abstract:Under the new background, new situation and new requirements, in order to clarify the research hot topics and development context of collaborative innovation in Industry-University-Research, 570 high-quality literatures in CNKI from 2007 to 2021 were taken as samples, and CiteSpace, a bibliometric analysis software, was used for visual analysis, showing the trend of starting articles, the co-occurrence, clustering and timeline map of keywords. The results show that the domestic research hotspots mainly focus on the connotation, theory, mode and mechanism of collaborative innovation in Industry-University-Research, and scientifically and systematically answer the key questions of "what", "why" and "how to do it" in Industry-University-Research. However, the research hotspots in different periods have changed significantly and are closely related to the national conditions, from exploring the path of Industry-University-Research's organizational model in the early stage to gradually paying attention to the institutional guarantee of educational reform, policy incentives and intellectual property protection, and then emphasizing the innovation environment under the background of intensified international innovation competition. Based on the research results, it is analyzed and judged that the basic trend of collaborative innovation in Industry-University-Research in China is that the guiding role of the government, the supporting ability of knowledge and the nurturing function of the environment will be further strengthened.