Abstract:This paper takes 265 literatures as the research object, which is about research of College Students' innovation and entrepreneurship in CSSCI database from 2000 to 2018. It visually analyzes and compares the literatures by using Bibliometric Analysis and CiteSpace from the aspects of author cooperation, co-citation, keyword co-occurrence and so on, and draws the knowledge graph. The result shows that most scholars in the field of College Students' innovation and entrepreneurship conduct research in the form of small-scale cooperation, lack of cooperation, and have not formed a complete and mature academic system.The research mainly focus on innovation and entrepreneurship education, entrepreneurship policy, entrepreneurship intention, innovation and entrepreneurship ability, etc. Educational Research, China Higher Education, Educational Development Research and other journals are the main communication carriers, among which, the field of education, enterprise management and science and technology management have the greatest impact on College Students' innovation and entrepreneurship.