Abstract:The change of world pattern and the development of industrial revolution are important historical opportunities for late-developing countries to achieve scientific and technological catch-up and build a world scientific and technological power. Germany became a world power in science and technology by leading the second industrial revolution; the United States seized the opportunity of the second industrial revolution and the two world wars to overtake Europe and become a world power in science and technology and lead the third industrial revolution; Japan seized the opportunity of the convergence of the second and third industrial revolutions and successfully joined the ranks of world powers in science and technology.From economic rise to scientific and technological catch-up, from technology introduction to original innovation, from educational reform to scientific development, from spontaneous innovation to system construction, all three late-developing countries have developed endogenous technological capabilities, continuously built their talent pool, promoted scientific and technological innovation and institutional innovation,and focused on the leading role of national research institutions.Accordingly, this paper puts forward relevant suggestions on self-reliance and self-improvement in science and technology, integration of science and education, open cooperation in science and technology, and construction of national strategic science and technology force system.