Abstract:In view of the lack of regional innovation evaluation ,integration of regional development planning and target positioning, we explore the combination of target value method and benchmarking analysis method on the basis of domestic and foreign innovation evaluation methods, and construct from the dimensions of innovation resources, enterprise innovation, innovation performance, and innovation environment. The urban innovation index evaluation index system including 20 basic indicators uses the comprehensive index evaluation method to monitor and evaluate Guangzhou's scientific and technological innovation capabilities. The calculation results show that the overall level of scientific and technological innovation in Guangzhou has been improved, the effect of agglomeration of innovation resources has become more prominent, the innovation vitality of enterprises has been increasingly enhanced, the performance of scientific and technological innovation has been significantly improved, and the environment for innovation and entrepreneurship has been continuously optimized; however, further analysis can be seen, the supporting role of the modern service industry and the construction of the incubation system still need to be strengthened. Finally, the paper puts forward some policy suggestions to promote the scientific and technological innovation and development of Guangzhou, such as improving the investment intensity of research and development funds and the technological innovation ability of enterprises, guiding the innovative development of modern service industry, and accelerating the incubation and cultivation of technological enterprises.