提出合作创新韧性的概念，认为合作创新韧性是区域稳定合作创新网络对抗新冠疫情冲击的重要能力。基于演化经济地理学的相关理论，利用2017—2020年中国合作专利申请微观数据及中国内地30个省域数据，探讨创新投入多样化对合作创新韧性的直接作用，以及其通过经济结构影响合作创新韧性的间接作用。研究发现：疫情期间，由于研发预算软约束、市场不确定性和线下交互受阻等因素，冲击具有结构偏向性，对基础研究和应用研究的影响更大，表现为创新投入越多样化的省市创新韧性（对冲击的抵抗能力）则越弱；创新投入多样化通过调节产业结构的升级和企业结构影响创新韧性，疫情对不同产业结构和企业结构的地区影响具有异质性；产业结构具有完全中介效应，企业结构具有部分中介效应。

The concept of cooperative innovation toughness is put forward. It is considered that the resilience of innovation is an important capability of regional cooperation innovation network against COVID-19. Based on the relevant theories of evolutionary economic geography, this article discusses the direct effects of innovation diversification on innovation resilience and its indirect effects on innovation resilience through economic structure. The paper finds that: (1) During the COVID-19 pandemic, due to factors such as soft constraints on R&D budgets, market uncertainty, and blocked offline interactions, the impact was structurally biased and had a greater impact on basic research and applied research. Provinces and cities with more diversified innovation inputs have weaker innovation resilience ,as resistance to shocks. (2) The diversification of innovation input affects innovation resilience by regulating the upgrading of industrial structure and enterprise structure. The regional impact of COVID-19 on different industrial and corporate structures is heterogeneous. The industrial structure has a complete mediation effect, and the enterprise structure has a partial mediation effect.

F061.5；F062.3；F124.3?

国 家 自 然 科 学 基 金 青 年 项 目“ 失 败 学 习 形 成 机 制 及 其 对 后 续 创 新 绩 效 的 影 响 研 究 :基 于 复 杂 产 品 创 新 失 败 ”(71902045);广东省重点平台及科研项目“大湾区背景下科技资源向高新企业流动政策障碍研究”(2017WQNCX173)