Abstract:Innovation community is an important measure to strengthen the urban agglomeration spatial coordination and promote the regional economy high-quality development. Based on innovation community characteristics of cross regional synergy and spillover effect, this paper adds spatial factors and local protectionism, constructs the innovation community evolutionary game model in the Yangtze River Delta from the synergy perspective, and uses case simulation to describe the dynamic evolution process and important influencing factors. The research shows that: Government intervention plays an important role in innovation community. Factors such as intellectual property protection and government support have a positive effect on system evolution in the direction of collaborative innovation. The greater the strength, the faster the convergence speed of the system; local protectionism and spatial distance have a negative effect on the system evolution to collaborative innovation. When it exceeds a certain threshold, it is difficult to form a community; The academic quality has a positive effect on the evolution of the system towards collaborative innovation; There is an optimal range for the enterprises and researchers efforts, which can promote the collaborative innovation evolution in game direction. The conclusion has important practical significance for a comprehensive understanding of the innovation community construction and evolution, promoting the benign interaction between regions and realizing regional economy high-quality development.