Abstract:China has not yet formed standardized documents or quality management systems for different stages of major scientific and technological projects. In order to promote the science and technology project management to achieve full process quality management and ensure the management is applicable, efficient, effective and sustainable, on the basis of combing and comparing the full process management mechanisms of science and technology projects formed by relying on professional institutions at home and abroad, taking the management of R&D plan projects in key fields of Guangdong Province as an example, according to PDCA cycle theory, combining the characteristics of Guangdong science and technology plan project management and relevant policy systems, a whole process quality management system of science and technology projects with the main line of "Project Plan - Project Decision - Process Supervision - Analysis Feedback" has been established. It is proposed that the whole process quality management mode of science and technology projects includes four stages: project plan, project decision, process supervision and analysis feedback. In the project plan stage, general management, technology and work standards applicable to science and technology plan management should be formulated; in the project decision stage, project review should be the core task; in the process supervision stage, it is necessary to focus on dynamic monitoring, risk identification, estimation and prevention, and establishment of standardized evaluation system in the project implementation process; in the analysis feedback stage, work should be carried out around the organization and implementation of performance evaluation and post evaluation of special management work. It is put forward suggestions on further optimizing and improving the whole process quality management of science and technology projects from the aspects of improving the information management mechanism, establishing the risk control mechanism, implementing the project specialist system and carrying out standardization construction.