Abstract:In order to promote the professional construction of the medical-industry-university-research collaborative innovation system in East China, we use the data of authorized invention patents in the region from 2004 to 2021 to analyze the medical-industry-university-research cooperation development status, and use the social network analysis method to analyze the evolution characteristics of its medical-industry-university-research patent cooperation network by taking 6-year as the time window. The results show that: from 2004 to 2021, the medical-industry-university-research cooperation in East China gradually developed into a network with a large scale and high cooperation density, and showed a relatively obvious evolution trend in different periods. The network scale and cooperation frequency continued to increase. The number and scale of sub-networks also showed an increasing trend; Shanghai, Jiangsu and Zhejiang played a leading role, among which the universities headed by Zhejiang University and the research institutes headed by the Shanghai Institute of Materia Medica of Chinese Academy of Sciences played a particularly prominent role, and the universities and research institutes occupied the core position of the network, and gradually formed a multi-center cooperation sub-network, while large pharmaceutical companies did not play an important role. According to the research findings, countermeasures and suggestions to further promote the collaborative innovation and development of medical-industry-university-research in East China are put forward from the aspects of accelerating the transformation of technological achievements, stimulating the leading role of core nodes, strengthening the dominant position of enterprises, and improving the participation of medical institutions.