Abstract:Innovation ability is one of the key factors to promote high-quality development. Based on the configuration perspective, with 31 provinces in China as case analysis samples, the fsQCA method is used to explore the driving factors of regional innovation capabilities and the interaction between factors. The study found that high technology is a necessary condition for improving the level of regional innovation, high-tech talents and high-tech enterprises are necessary factors to promote the improvement of regional innovation; there are 5 driving paths that form a high level of innovation in the region, and 4 paths for low innovation levels. There is an asymmetric relationship between the two; under certain objective endowment conditions, there is an alternative relationship between government, market, organization and other driving factors, and the level of regional innovation can be improved through mutual substitution. The research conclusions help to deepen the rational understanding of the complex nature of the multiple factors behind the improvement of the regional innovation level, and can provide useful reference and enlightenment for the realization of regional innovation-driven development.