Abstract:High level scientific research papers are the main carrier of basic research achievements. In or-der to scientifically grasp Guangdong's position in domestic scientific and technological com-petitiveness, the paper uses access, CiteSpace and other tools and Boston matrix analysis meth-od to make a quantitative and qualitative analysis of Guangdong SCI papers from 2010 to 2019 from the dimensions of paper output, excellent papers, international cooperation papers and dis-ciplinary advantages. The results show that the number of SCI papers in Guangdong ranks the fourth in the country, and the growth rate ranks the first in the country. The citation intensity of papers has increased significantly; However, Guangdong still lags behind Beijing and Shanghai in the quantity and quality of SCI papers, basic research output and discipline construction. To build Guangdong into a strong province of scientific and technological innovation at a higher level, it is necessary to further strengthen the emphasis on basic research, introduce and cultivate excellent scientific and technological personnel, create new disciplinary advantages, and create academic exchange platforms such as high-level scientific and technological journals.