Abstract:Talent revitalization is the key to the in-depth implementation of the Rural Revitalization Strategy. Opening up the channel of talent transportation in Colleges and universities and integrating into the construction of Rural Revitalization is an effective way to gather talents in many ways. Therefore, the cultivation of innovative and entrepreneurial talents in Colleges and universities will also meet new challenges. Taking Guangxi as an example, through empirical research,this paper understands the main problems and difficulties existing in the current cultivation of innovative and entrepreneurial talents in Colleges and universities, starts with the construction of characteristic mode,and puts forward the strategy of ecological construction of innovative and entrepreneurial talents cultivation from five aspects: innovative concept,platform construction,improving system,integrating resources and promoting cooperation,so as to provide guarantee for creating a new situation of Rural Revitalization.