Abstract:The difficulty of patent valuation is the main obstacle for financial institutions to handle patent pledge financing business. By disguising patents, low-tech companies prevent financial institutions from confirming their technological level through loan signals, which has led to the problem of "patent signal failure". This paper analyzes the cause and harm of this phenomenon through a signal game model, then discusses the interaction mechanism between industry-university-research collaboration and patent pledge financing. The results show that industry-university-research collaboration can help reduce the information asymmetry between borrowers and lenders in the patent pledge market, thereby alleviating the market inefficiency caused by “patent signal failure”. On the other hand, patent pledge financing can also have a positive impact on the decision-making of industry-university-research collaboration of science and technology enterprises. In this regard, it is recommended to actively improve the construction of industry-university-research cooperation platforms, take industry-university-research collaboration as an important consideration to help financial institutions identify reliable patent signals. At the same time, more diversified financing channels should be provided to small and medium-sized enterprises that do not yet have high-quality patent output but are engaged in technological cooperation with high-level scientific research teams.