Abstract:Under the background of domestic and international double circulation and in-depth implementation of the innovation driven development strategy, China"s economy has transformed from high-speed growth to high-quality development. Good scientific and technological innovation can promote the high-quality economic development of the national independent innovation demonstration zone. Taking fuxiaquan national independent innovation demonstration zone as an example, this paper selects the municipal regional statistical data in the self created zone from 2016 to 2020, constructs the coupling and coordination model of high-quality economic development and scientific and technological innovation of urban agglomeration National Independent Innovation Demonstration Zone on the basis of entropy method and grey correlation analysis, and makes an empirical analysis. The research draws the following conclusions: from the perspective of the development level of scientific and technological innovation, the comprehensive level of scientific and technological innovation development in the self creation zone shows an overall growth trend, but there are significant differences among cities; From the perspective of high-quality economic development level, there is a large gap in the high-quality economic development level of various cities; From the perspective of time trend, the coupling and coordination degree between scientific and technological innovation and high-quality economic development in the self creation zone generally shows a slow growth trend; From the perspective of spatial pattern, there is a gap in the degree of coupling coordination among cities. The degree of coupling coordination in Xiamen is slightly higher than that in Fuzhou, while the degree of coupling coordination in Quanzhou is relatively low; The correlation between innovative development and coordinated development is the strongest, and the correlation between scientific and technological innovation and high-quality economic development subsystems in Fuzhou is the highest. Finally, based on the research conclusions, this paper puts forward policy suggestions for the national independent innovation demonstration zone to strengthen scientific and technological innovation and promote high-quality economic development.