Abstract:Promoting the layout and construction of the national scientific and technological innovation center has important practical significance for building a new development pattern, promoting regional coordinated development, and creating the main engine of innovation. Based on the actual construction of regional scientific and technological innovation centers in China, this paper compares and analyzes the scientific and technological innovation development foundation of major regions and urban agglomerations, and puts forward the priority choice for the construction of regional scientific and technological innovation centers in China in the new era. On this basis, the foundation and advantages of the construction of Xi'an and Lanzhou national regional science and technology innovation center are analyzed in a multi-dimensional comparative way, and suggestions are put forward, such as the combination of "point, line and plane", the construction of "pearl shaped" science and technology corridor and 10 innovation consortia with "qinchuang Park" and "longchuang belt", the active integration into national major regional strategies, and the exploration of the establishment of a cooperative mechanism of synergy, high efficiency, high energy and mutual benefit.