Abstract:Radical innovation plays an important role in improving the quality of technological innovation of enterprises and achieving leapfrog development, which is closely related to cross-field and cross-industry knowledge integration. Based on the knowledge-based view, this paper explores the mechanism of the knowledge integration capacity based on exploratory innovation on the enterprise’s radical innovation, and further explains the moderating role of the enterprise’s absorptive capacity and innovation openness. Through the data analysis of 457 listed companies in China’s computer communication and electronic equipment manufacturing and pharmaceutical manufacturing industries from 2012 to 2019, it is found that the ability of creative knowledge integration to promote radical innovation is greater than the ability of hybrid knowledge integration; Both absorptive capacity and innovation openness have a positive moderating effect on the positive influence of hybrid knowledge integration and radical innovation, but neither play a role in the impact mechanism of creative knowledge integration on radical innovation. This paper not only provide new ideas for how to improve radical innovation through cross-domain and cross-industry technology integration, but also put forward relevant suggestions for how to improve dynamic capabilities and strengthen cross-organizational collaboration.