Abstract:The Guangzhou key field R&D plan is one of the most important science and technology plans after the reform of Guangzhou's science and technology planning system, and it is the most representative major science and technology project. Based on the first batch of five special projects and 24 directions of the Guangzhou key field R&D plan, this paper analyzes the basic characteristics and key points of the Guangzhou key field R&D plan from the application guidelines, types of undertaking units, funding and other aspects. There are problems, and think about three aspects: grasping the top-level design, improving the project review mechanism and strengthening the management during the implementation period, and proposes to optimize the formulation of the application guidelines, rationally allocate special financial funds, explore diversified review methods, improve the selection of review experts, and improve project funding. Suggestions on the disbursement system, optimizing the project organization and management mechanism, and giving full play to professional strength to strengthen project management provide a reference for improving and optimizing the organization, implementation and management of major science and technology projects in Guangzhou, and for relevant local government departments to formulate industrial development policies and plans.