Abstract:This paper first analyzes the basic situation of forming the center city of scientific and technological innovation in inland areas, it is pointed out that some big cities in inland areas are facing the historic opportunity to develop the science and innovation industry, and have initially obtained the scientific and technological resources and economic basis to nurture the science and innovation industry. However, there are also many problems such as lack of innovation atmosphere, insufficient investment in innovation, lack of science and innovation enterprises and supporting service institutions.Then, this paper puts forward the mechanism and path of science and technology innovation center in inland cities, that is, to build a system and policy environment conducive to science and technology innovation, form a regional innovation ecosystem with research-oriented universities and scientific research institutions as the innovation power source, science and technology enterprises as the leader, and first-class law, accounting, auditing, information services and financing institutions as the intermediary.Moreover, close interaction with developed countries and coastal regions is needed to capture innovation spillovers.Finally, it is suggested that we should avoid excessive investment, repeated investment and economic financialization in the construction of inland science and innovation center cities, so as to achieve inclusive development.