Abstract:At present, due to the weak foundation of scientific and technological innovation, most of " the Belt and Road" countries are lack of willingness and basis for cooperation in scientific and technological innovation . The depth of international scientific and technological cooperation among them needs to be strengthened. The content and mechanism of such cooperation between China and these countries also need to be further enriched and improved. By drawing experiences from international cooperation in such field between developed countries/regions such as the United States, the European Union, Germany, Japan, Singapore and developing countries/regions, four common characteristics are concluded: building a multi-level scientific and technological exchange platform and deepening people-to-people exchanges in science and technology field; wisely arranging international cooperation bases in such field and broadening such cooperation networks; establishing sound overseas incubators and creating a BRI featured innovation cooperation system; promoting joint technological research and improving the level of scientific and technological aid. China can draw useful practices from it, and explore a creative model for BRI cooperation in scientific and technological innovation with Chinese characteristics according to the development stage and practical needs of itself and countries under the BRI Scheme. It is suggested to focus on exploring the construction of a cooperative ecology of coordinated innovation and coordinated development of multiple elements such as talent, technology and space surrounding scientific and cultural exchanges, scientific and technological cooperation networks, featured innovation cooperation systems, level of scientific and technological aid; and promote steady and long-term BRI international cooperation in scientific and technological innovation by enhancing our voice in international science and technology, effectively complementing each other and cooperating in scientific and technological aid.