Abstract:This paper takes 28 provinces and cities in mainland China as research samples, applies fuzzy-set qualitative comparative analysis (fsQCA) methods, selects five representative variables from the two dimensions of strategic coordination and scientific and technological resource allocation, and discusses the driving factors affecting the performance of scientific and technological innovation in universities.The study found that the overall performance of scientific and technological innovation in universities is relatively low and the regional heterogeneity is strong. The allocation of human resources is a necessary condition for improving the performance of scientific and technological innovation in universities. There are regional differences in the choice of paths, and there are three performance improvement paths including resource collaborative allocation type, resource internal allocation type, and talent-led collaborative type. Finally, corresponding countermeasures and suggestions are put forward.