Abstract:To explore the performance of enterprises in our country has high open innovation path, under the background of the innovation environment different, this article selects the 19 typical enterprise in China and the United States, using QCA value set more qualitative comparative analysis method, comparative analysis of open innovation enterprise of China and the United States a variety of conditions. The results show that: (1) There are two paths for Chinese and American firms to achieve high open innovation performance. (2) The successful firms all have good intellectual property protection environment and good industry-university-research cooperation. (3) For Chinese and American enterprises, the absence of both foreign direct investment and industry-university-research cooperation will lead to the decline of open innovation performance. Based on these, some suggestions are put forward for the open innovation of Chinese enterprises.