Abstract:Improving the technological innovation efficiency of enterprises is beneficial to the long-term development of enterprises, and the correct choice of R&D mode affects the innovation path of enterprises. To explore the influence of different R&D modes of pharmaceutical manufacturing industry on technological innovation efficiency under the guidance of heterogeneous knowledge base, the three-stage DEA and Tobit model were used to make an empirical analysis of the data of pharmaceutical manufacturing industry from 2015 to 2020. The results show that: for the pharmaceutical manufacturing industry, cooperative innovation can improve the technological innovation efficiency of enterprises. Under the guidance of heterogeneous knowledge base, compared with independent innovation mode, cooperative innovation can improve the technological innovation efficiency of H-L company and L-L company. For L-H Company, independent innovation can improve the efficiency of technological innovation; However, the two R&D modes of H-H Company have no significant advantages in technological innovation efficiency.