提高企业技术创新效率有利于企业长远发展，研发模式选择正确与否影响着企业的创新之路。为探究医药制造业在异质知识基础导向下不同研发模式对技术创新效率的影响，采用三阶段DEA和Tobit模型对医药制造业2015-2020年的数据进行了实证分析。研究结果发现：对于医药制造业而言，合作创新更能提升企业技术创新效率，在异质知识基础导向下，对于H-L公司、L-L公司而言，相比于自主创新模式，合作创新更能提升技术创新效率；对于L-H公司而言，自主创新更能提升技术创新效率；而H-H公司两种研发模式对技术创新效率并没有显著性优势。

Improving the technological innovation efficiency of enterprises is beneficial to the long-term development of enterprises, and the correct choice of R&D mode affects the innovation path of enterprises. To explore the influence of different R&D modes of pharmaceutical manufacturing industry on technological innovation efficiency under the guidance of heterogeneous knowledge base, the three-stage DEA and Tobit model were used to make an empirical analysis of the data of pharmaceutical manufacturing industry from 2015 to 2020. The results show that: for the pharmaceutical manufacturing industry, cooperative innovation can improve the technological innovation efficiency of enterprises. Under the guidance of heterogeneous knowledge base, compared with independent innovation mode, cooperative innovation can improve the technological innovation efficiency of H-L company and L-L company. For L-H Company, independent innovation can improve the efficiency of technological innovation; However, the two R&D modes of H-H Company have no significant advantages in technological innovation efficiency.

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