Abstract:The "Three reviews" reform put forward targeted reform measures for project evaluation, talent evaluation and institutional evaluation, which greatly promoted the scientific development of the scientific and technological evaluation mechanism. In the context of the new requirements of the "three reviews" reform, this paper takes the major science and technology project science and technology as an example, and deeply studies the construction of the major science and technology project science and technology evaluation mechanism. The research believes that there are still problems in the current scientific and technological evaluation, such as the expert selection system still needs to be improved, the evaluation standards are unreasonable, and the supervision of the evaluation experts is insufficient. Based on this, this paper introduces the responsibility list system. Based on the perspective of the responsibility list system, it is proposed that the future should be improved from four aspects: improving the scientific and technological evaluation mechanism, strictly regulating the expert selection system, improving the scientific and technological evaluation index system, and improving the construction of the evaluation team and the organization level. Major scientific and technological special evaluation mechanism.