Abstract:Disruptive innovation has burst out with amazing market potential, which is becoming a new trend in the innovation and development of start-ups, and the collaborative cooperation of innovation ecology has solved the innovation weakness of start-ups. Therefore, based on the perspective of innovation ecology, this paper divides innovation ecology into innovation political ecology, innovation technology ecology and innovation market ecology, deeply analyzes the mechanism of innovation ecology on the disruptive innovation of start-ups, and on this basis, analyzes the mediating effect of innovation ecological ability and the moderating effect of innovation ecological environment, constructs a theoretical analysis framework and puts forward theoretical propositions, It provides a theoretical reference for the research on Disruptive Innovation of start-ups.