Abstract:Taking nuclear power engineering construction enterprises as an example, this paper proposes a management model that taking demand-side as the traction, operate modular organization and full-cycle and full-process project management methods to support for the management of key core technologies research projects in nuclear power field. Taking the scientific and technological achievements and the transformation of achievements as goals, uses modular organization and project management methods as a starting point, to optimally allocate resources, make realization of full-cycle and full-process management for projects, and improve management efficiency of scientific and technological project . This management model can provide theoretical and practical reference for the key core technology research projects in other fields.