Abstract:Explore the innovative combination mode of the bio-pharmaceutical industry cluster, and further expand the systematic research on the macro and micro level of the innovative combination mode of the bio-pharmaceutical industry cluster. Using the social Network theory, based on the relevant patent cooperation data from 2013 to 2021, the innovation cooperation network of Jiangsu's bio-pharmaceutical industry cluster is constructed. The overall network characteristics and the change trend of innovation combination mode are analyzed macroscopically, and the core subjects are grasped microscopically through the analysis of individual centrality. The results showed that the bio-pharmaceutical industry cluster in Jiangsu Province has not yet formed a technological innovation cooperation ecosystem; The innovation combination model has evolved from a chain structure to a modular structure and then to a cluster structure. The innovation cooperation model of industry university research organizations is the mainstream force, and universities and research institutes have shown great advantages. However, enterprises are mostly located at the center of the network. Finally, suggestions were put forward to promote the formation of a chain, modular, and clustered ecological innovation combination model for the bio-pharmaceutical industry cluster in Jiangsu Province.