Abstract:The Law of the People's Republic of China on Scientific and Technological Progress (2021 Revision) has provided systematic provisions on the management of scientific research projects, but there are still some problems such as lack of local laws and regulations on the management of scientific research projects. This article focuses on the comprehensive scientific and technological regulations in Shanghai, Guangdong, and other places, compares and analyzes the similarities and differences among these regions on the organization mode, project management, fund management and performance evaluation. Tt is expected to provide references for the implementation of the law on the progress of science and technology and the improvement of laws and regulations on the management of scientific research projects. Research has found that regulatory models and organizational types of scientific research project management are different in these regions. Such as three types of regulation modes: principle regulation, classification regulation and mixed regulation. And four kinds of organization modes, such as conventional organization mode, directional entrusting, "select the best candidates to undertake key research projects" and “new system for mobilizing resources nationwide”, have solidified into local laws and regulations. There are many kinds of scientific research projects in these local laws and regulations, but their scope boundaries are not clear. their contents of regulation for the management of scientific research projects are similar, and form their own complete system in each regulation. All of them stipulate the way of project organization, scope of application subjects, open cooperation, scientific research integrity and due diligence exemption. However, there are differences in the relevant provisions of overseas research and development institutions and military related subjects. The provisions on the use of scientific research funds mainly involve the scope and the principles of use of funds, and the autonomy of researchers, as well as the autonomy of researchers. For example, the scope of use of financial funds in Guangdong Province and Shenzhen has been extended to Hong Kong and Macao. All of these local regulations have established their own evaluation system based on scientific research integrity, and mainly stipulates scientific research performance from the perspective of tolerance of failure or due diligence exemption. However, there are few specific regulations on the performance management of project funds.Finally, it puts forward the countermeasures and suggestions to improve the management regulations of scientific research projects in various regions from four dimensions: establishing a legal system for scientific research project management, improving the classification management system for scientific research projects, clarifying the legal bottom line for the use of scientific research funds, and establishing a tolerance mechanism based on scientific research integrity.