Abstract:Under the background of the new development pattern, the paper deeply analyzes the practical basis and existing problems of the innovation ecosystem in the Guangdong Hong Kong Macao Greater Bay Area, proposes to build a "double cycle" ecosystem of scientific and technological innovation in the Guangdong Hong Kong Macao Greater Bay Area, and expounds the construction and operation mechanism of the "double cycle" ecosystem of scientific and technological innovation from the perspective of innovation resource flow and allocation. It is proposed to build a domestic circulation system of scientific and technological innovation with the "Guangzhou Shenzhen Hong Kong, Guangzhou Zhuhai Macao Science and Technology Innovation Corridor" as the axis, so as to improve the ability of independent innovation; Build an international circulation system of scientific and technological innovation with the "the Belt and Road" as the core, and form a high-level open innovation pattern; From the aspects of improving the free flow mechanism of innovation resources, the protection and application mechanism of intellectual property rights, and the flow mechanism of talents, this paper discusses the dynamic mechanism of realizing the international and domestic double circulation and mutual promotion of scientific and technological innovation.