Abstract:The government plays a leading role in China’s national innovation system. At present, the research on government behavior and regional innovation capability lacks the discussion of complex mechanisms under multiple conditions. Based on the characteristics of direct participation and indirect promotion in government organization behavior, this paper uses the Time Differencing QCA to explore the feasible path to enhance China"s regional innovation capability under the leadership of the government. The research found that the government behavior path that can achieve the high-level development of regional innovation capability during the "13th Five Year Plan" period includes four types, namely, resource input type, coordinated development type, infrastructure type and economic leading type. Among them, resource input path plays a more important role in promoting regional innovation capability, and it is a feasible choice to rapidly and effectively enhance regional innovation capability. The research conclusion of this paper is helpful to dynamically reveal the internal logic of different combinations of government behaviors affecting regional innovation capability, and provide policy enlightenment for the government to effectively integrate innovation resources, use the "light hand", and seek practical innovation paths.