Abstract:The influencing factors of the regional selection of the transformation of major scientific and technological achievements can be summarized into five aspects: supply side, demand side, service side, government policy and factor allocation. The research results of expert consultation and questionnaire survey show that the third-party service and channel factors, relevant innovation subjects' R&D energy level, resource allocation factors, demand side factors, accidental factor drivers, core factor drivers are particularly important. The way to improve the regional synergy efficiency of the transformation of major scientific and technological achievements is to increase the allocation of factor resources for the transformation of achievements in major regional fields, highlight the leading position of enterprises and demanders in the region, and strengthen the transfer and transformation services of scientific and technological achievements.