Abstract:Guangdong gives full play to the important advantages of the scale of cultural industry and regional scientific and technological innovation ability, vigorously implements the integration strategy of integrating culture and science and technology, and makes beneficial exploration of the integration mode of culture and science and technology, while, further research on the challenges and path of improvement and optimization will help to promote the promotion of cultural, scientific and technological innovation ability and enhance the core competitiveness of the cultural industry. On the basis of combing and analyzing the theoretical connotation of the integration of culture and science and technology, and the typical development models and paths at home and abroad, this paper summarizes the specific modes and measures of the integration of Guangdong culture and science and technology, analyzes the main existing problems and puts forward targeted countermeasures and suggestions.The results show that, in the integration of culture and science and technology, Guangdong mainly explores three modes of the government policy driven, market demand driven and technology driven, and supporting specific measures, to provide strong support for the rapid development of the cultural undertakings and cultural industry. However, compared with other advanced regions at home and abroad, its development is still relatively lagging behind, the innovation consciousness and innovation ability of the cultural industry are not strong, the application of modern science and technology and the mining of Lingnan cultural characteristics need to be strengthened, the main manifestations are that the support policy system needs to be improved, the roll doubles problem of culture and technology needs to be solved, the key technology ability needs to be improved, and the supply of compound talents is insufficient. Finally, it is proposed that Guangdong should give full play to the unique advantages of deep and rich Lingnan culture and leading regional innovation ability, and further improve the top-level design and policy measures of the integration of culture and science and technology, focus on technological innovation, base construction, industrial digitalization, and personnel training to promote the deep integration of culture and science and technology, and enhance the core competitiveness of the cultural industry.