Abstract:At present, the development of international scientific and technological innovation is changing with each passing day, and the international situation is complex and changeable. It is urgent to continuously strengthen the national strategic scientific and technological strength. The scientific and technological innovation base is an important starting point for building a national strategic scientific and technological force. It is urgent to optimize and integrate the scientific and technological innovation base. Based on the perspective of innovation value chain, this paper analyzes the development status of China's major scientific and technological innovation bases by collecting policy texts and second-hand data, finds out the main problems and puts forward optimization suggestions. The research found that the function orientation of the scientific and technological innovation base is unclear, Management coordination is difficult, and the collaborative mechanism for sharing and co-construction is not perfect. The suggestions were put forward to clearly optimize the function orientation of the scientific and technological innovation base, establish a collaborative development committee, optimize the layout and investment of the basic research base, and improve the resource sharing and circulation mechanism between the bases.