Abstract:Unlike the existing related research which focuses on the overall characteristics of the industry-university-research cooperation network and its influence, we further explore the influence of the characteristics of the different property of the cooperation network in the industry-university-research cooperation due to the different subjects on the innovation performance of the enterprises, and we select the pharmaceutical manufacturing enterprises which are rich in patents and have extensive cooperation in innovation, and select the data of joint patent applications of the pharmaceutical manufacturing enterprises listed on the main board of the A-share stock market of China during the period 2010-2021 as the samples. We constructed "enterprise-enterprise", "enterprise-university" and "enterprise-institute" patent cooperation networks by social network analysis, and verified the effectiveness of network structure indexes in each type of cooperation networks by negative binomial regression. The results show that structural holes in the " enterprise-enterprise " and " enterprise-institute " sub-networks have a significant effect on enterprises' innovation performance. In the sub-network of "enterprise-university", structural holes have a non-linear and inverted "U" shape relationship with enterprise innovation performance, and when the constraint of enterprise structural holes reaches 0.526, its promotion effect on enterprise innovation performance reaches the maximum. In the sub-networks of "enterprise-enterprise" and "enterprise-institute", the centrality of the enterprise's neighborhood degree promotes the enterprise's innovation performance and mediates the effect of structural holes on the enterprise's innovation performance. Accordingly, it is proposed that pharmaceutical enterprises should have a clear understanding of their own innovation needs and the location and property of the network in which they are located, so as to make full use of the characteristics of networks of different properties to better carry out innovation cooperation and improve innovation performance.