Abstract:Analyzes the theoretical mechanism of digital infrastructure driving regional innovation, and empirically examines the regional innovation effect of digital infrastructure using China's inter provincial Panel data. The research found that: Digital infrastructure investment significantly promotes the improvement of regional innovation, and is achieved through channels including independent R&D, technology introduction, knowledge supply and innovation transformation; The innovation effect of digital infrastructure investment on the eastern region is greater than the central region, and the effect on the central region is greater than the western region, the effect on the basic research is greater than the applied research, and the effect on the high-quality innovation is greater than the low-quality innovation; With the improvement of factor endowment, marketization and intellectual property protection, the promotion of digital infrastructure on regional innovation is increasing; Digital infrastructure investment can promote the transformation of China's innovation model from introduction and imitation to independent research and development. To further stimulate the role of digital infrastructure in driving innovation, it is necessary to strengthen supporting construction and take measures according to local conditions and structure.