Abstract:Exploring the impact of different modes of collaborative innovation among industry, university and research on the development of total factor productivity can provide useful insights for promoting the deep integration of industry, university and research and improving the quality of economic development. This paper distinguishes the total factor productivity from its growth rate, and analyzes the relationship between collaborative innovation of industry-university-research, and the total factor productivity and its growth rate, on the basis of using information entropy to measure the level of collaborative innovation among industry, university and research in 30 provinces and cities of China from 2009 to 2019, this paper examines the impact of collaborative innovation models of industry, university and research on total factor productivity and its growth rate, which can reveal the asymmetric effect of heterogeneous collaborative innovation of industry-university-research on the quality of regional economic development. The results show that:The impact of heterogeneous collaborative innovation of industry-university- research on the total factor productivity is asymmetric. The bilateral collaborative innovation of industry-university and university-research has an increasing promoting effect, while the trilateral collaborative innovation of industry-university-research has a decreasing inhibiting effect, in the channel of influence, only the industry-university bilateral cooperative innovation can improve the technical efficiency and promote the technical progress, and other cooperative innovation models can not promote the technical progress;The impact of heterogeneous collaborative innovation on total factor productivity is asymmetric among regions, and the promotion effect is more obvious in the central and western regions, but the main effect is to improve technical efficiency;The lag period test is considered and find collaborative innovation between academics and research institutes in both sample and the central and western regions will continue to drive the next stage of technological progress, which can provide long-term impetus for the upgrading of total factor productivity and the quality of regional economic development.