Abstract:[Purpose/significance] National research institutions are important promoters of open science. This article analyses the motivations that promote the process of NASA’s open science, sorts out its development system and practice path, and to provide decision-making reference for the development and practice of open science of scientific research institutions in China;[Method/process]Through literature research and website survey methods to sort out and analyze the promotion of NASA from open access to open science, summarized its practical experience in promoting the development of open science; [Result/conclusion]NASA, as an important global aerospace scientific research institution and source of scientific data, aimed at greater scientific discoveries, has implemented good practices in open science data, open data infrastructure, public participation and establishment of multi-subject cooperation network, etc. We can make use of NASA’s development experience for reference to promote the development of open science in the light of our own national conditions, take open science construction as a grasp and to promote scientific innovation and development.