Abstract:China’s economy has shifted from the rapid development stage to the high-quality development stage. Promoting regional high-quality development requires the support from high-quality institutional mechanisms and policy systems. Innovation is the primary force driving the high-quality development. To fulfill the setting goals of high-quality development, new theories are in need to explain, construct, and guide the transformation of regional economic growth and development models. In a nutshell, smart specialization is a new innovation theory, which has offered a new policy making logic for regional innovation-driven high-quality development. Therefore, by systematically tracing the theoretical path of innovation-driven high-quality development, the necessity of regional innovation-driven high-quality development is clarified, the core concepts and logical structure of smart specialization are analyzed, and the policy ideas for high-quality development of regional innovation are provided. By using case study method, a system and mechanism suitable for the high-quality development has been introduced from three aspects, thus flexible innovation policy combination, efficient capital support system and clear operation and supervision mode, which can form a high-quality institutional supply capacity and effectively support regional innovation-driven high-quality development.