Abstract:China’s state key laboratory system drives innovation in science and technology. In order to be more internationally competitive, international scientific and technological cooperation and communication has become one of the important indicators to evaluate the operation of state key laboratories. From the perspective of social capital theory, this paper explores the impact and influence mechanism of international scientific and technological cooperation in state key laboratories on their domestic scientific research performance. The papers, published by 230 state key laboratories in eight fields, and indexed in the Web of Science core collection will be taken as the data source. Using international cooperation paper data to construct the international cooperation network of state key laboratories and using the number of non-international cooperation papers to characterize the domestic scientific research performance of state key laboratories, the negative binomial unbalanced fixed effect panel Model is adopted, to empirically analyzes the impact of social capital such as cooperation scale, "bridge", and cooperation intensity in international cooperation networks on the domestic scientific research performance of state key laboratories. The study shows that: The scale of the international cooperation network and the intensity of cooperation between state key laboratories and overseas scientific research institutions have an inverted “U”-shaped impact on their domestic scientific research performance, which first increases and then decreases, and the inhibitory trend becomes more obvious as they cooperate with each other for a longer time. The higher the degree to which a state key laboratory serves as a "bridge" in the international cooperation network, the stronger the positive impact on its domestic scientific research performance. Thus, state key laboratories should seek more cooperation with world-class scientific research institutions and actively occupy a favorable position in the international cooperation network to expand access to non-redundant information.