Abstract:Abstract: This paper reviews the relevant literature on the construction of global science and technology innovation centers. Based on innovation ecosystem theory, the research constructs the innovation ecosystem framework of the global science and technology innovation center of Guangdong-Hong Kong-Macao Greater Bay Area(GBA) from the main components of innovation subjects, innovation resources, innovation capabilities and innovation environment. Then analyzes the realistic foundation and restrictive factors of its construction.Through field investigation and case analysis, the paper summarizes four innovation practical models for the construction of global science and technology innovation center in GBA, namely: emerging industry aggregation model, research and development institution aggregation model, university park aggregation model, and regional research platform aggregation model. Based on the research, the paper puts forward some suggestions on how to build a high-level global science and technology innovation center in GBA.