Abstract:The comprehensive national science Center is the basic platform for the construction of the national innovation system and the strategic carrier for the country to compete to become the next world scientific activity center. As the important combination point of science and technology the first productive force, talent the first resource and innovation the first driving force, the university will inevitably play an important supporting role. This paper analyzes the status quo of the role played by universities, especially local universities, in the construction of five comprehensive national science centers in Shanghai Zhangjiang, Anhui Hefei, Beijing Huairou, Guangdong-Hong Kong-Macao Greater Bay Area and Xi 'an, and takes Dongguan University of Technology as an example to fully participate in the practice and exploration of serving the pilot area of the comprehensive National Science Center in the Guangdong-Hong Kong-Macao Greater Bay Area. This paper puts forward countermeasures and suggestions on how local universities, which account for more than 90% of undergraduate universities, can effectively participate in supporting services in the construction of comprehensive national science centers, in order to provide reference for promoting the complementary advantages and win-win development of local universities and comprehensive national science centers.