Abstract:The willingness to collaborate on innovation among industry-university-research is a prerequisite and foundation for conducting collaborative cooperation and improving innovation efficiency. Therefore, it is necessary to explore its influencing factors and mechanisms. However, there is little research on the impact mechanism of market competition structure on collaborative innovation willingness, especially the superposition effect of different factors under different structures. Based on this, this article constructs a mathematical optimization model using the market benefits of collaborative innovation as the dependent variable (alternative variable of willingness), and the market competition structure (monopoly/competition), initial market demand, market growth potential, technology absorption capacity, and R D investment as independent variables. The theoretical results indicate that the effects of market growth potential and R D investment on collaborative willingness is influenced by the combined effects of market demand; These directions of action are opposite under different structures(competition or monopoly).Finally, based on the conclusion, some new ideas and insights are proposed.